What Makes ALect2 unique?
Amyloidosis is the abnormal deposition of protein in the tissue organs resulting in organ failure. There are 30 proteins known to cause amyloidosis in humans. Leukocyte Chemotactic Factor 2 (Lect2) is one of the most recently recognized types of amyloidosis, as well as one of the most common.14
In the United States, it typically presents with progressive kidney failure in elderly Hispanic patients. It is more commonly diagnosed in the Southwest Region of the country, although it can be seen in other regions of the country as well.10
It is not currently known if this is a familial amyloidosis, though it has been described in siblings. No definitive pathogenic genes have been associated with this disease.17 A kidney biopsy is currently required for definitive diagnosis.