Symptoms

• Presents as progressive renal disease14
• Progressive renal insufficiency with proteinuria only in some, usually non-nephrotic14
• Chronic renal insufficiency and bland urinary sediment17

Risk Factors

• ALect2 is most prevalent in the Southwest (New Mexico, Arizona, far western Texas). 10
• ALect2 presents on 2% of kidney biopsies from this region
• 54% of amyloidosis cases in the SW were ALect2. 10
• 88% of ALect2 patients in SW were Hispanic. 10
• Presents in patients between 43 and 88, with a mean age of 67. 2,5,7,8,10,11,13,17,18 

• Other groups with higher incidences are First Nation Peoples in Canada, Punjabis, and Native Americans. 5,8,10,13,17
• While the etiology of ALect2 is unknown and there is currently no effective treatment, it is important to avoid misdiagnosis. Applying ineffective treatment may be harmful. Regrettably, in one series 4 patients had received chemotherapy consequent to an erroneous diagnosis of AL.14