Figure adapted from Alect2 amyloidosis: primum non nocere (first, do no harm).14

Diagnosis

1. Congo red staining of a renal biopsy
2. Antibody or proteomic methods, such as mass spectrometry to type amyloidosis.14

Prognosis

• 1 out of every 3 patients developed end-stage renal disease.17
• Median renal survival was 62 months.17
• ALect2 is often misdiagnosed as an amyloidosis derived from immunoglobulin light chain (AL).14
• Creatinine levels have been suggested as a prognostic tool (See below).17

Treatment

• Currently, there is no effective treatment.14